General Information

  • ID:  hor005974
  • Uniprot ID:  P31745
  • Protein name:  Neurotensin
  • Gene name:  NTS
  • Organism:  Trichosurus vulpecula (Brush-tailed possum)
  • Family:  Neurotensin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Trichosurus (genus), Phalangeridae (family), Diprotodontia (order), Metatheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QLHVNKARRVYIL
  • Length:  13(1-13)
  • Propeptide:  QLHVNKARRVYIL
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Smooth muscle-contracting peptide.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005974_AF2.pdbhor005974_ESM.pdb

Physical Information

Mass: 182417 Formula: C73H124N24O17
Absent amino acids: CDEFGMPSTW Common amino acids: LRV
pI: 11.53 Basic residues: 4
Polar residues: 2 Hydrophobic residues: 6
Hydrophobicity: -16.15 Boman Index: -2772
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 142.31
Instability Index: 8052.31 Extinction Coefficient cystines: 1490
Absorbance 280nm: 124.17

Literature

  • PubMed ID:  1924896
  • Title:  Marsupial possum neurotensin: a unique mammalian regulatory peptide exhibiting structural homology to the avian analogue.